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Year : 2015  |  Volume : 28  |  Issue : 2  |  Page : 367-371

The use of podophyllotoxin for treatment of genital warts

1 Dermatogy, Andrology and S.T.Is Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Dermatogy, Andrology and S.T.Is Department, Quwesna Hospital, Shebin El-Kom, Egypt

Correspondence Address:
Samar M Fakhrey Abd El-Motaleb
Sheben El-Kom, Menoufia 32511
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1110-2098.163886

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Objective The aim of the study was to determine the clinical profile of genital warts (GWs) among Egyptians and evaluate the therapeutic effect of podophyllotoxin. Background External GWs are caused by proliferation of squamous epithelial cells secondary to human papillomavirus infection. It is sexually transmitted and affects sexually active adults and adolescents. The reason for its occurrence in children without evidence of sexual abuse is still unclear. There are several treatment options, but none has been proven to be the most efficacious. Patients and methods All patients complaining of GWs were recruited from the Dermatology Outpatient Clinic of Menoufia University Hospital during the period from March to September 2011. The patients were investigated for HIV and syphilis. Cervical Pap smear, colposcopy, and anoscopy were performed. Biopsies were taken from every patient to confirm the diagnosis. Podophyllotoxin 0.5% solution was used for treatment. Results A total of 140 cases of GWs were found among patients attending the Dermatology Outpatient Clinic, and included 100 female and 40 male patients (132 adults and eight children). A total of 120 patients received podophyllotoxin treatment and 20 were excluded as they were pregnant. Response to podophyllotoxin was variable and ranged from complete cure to absolute resistance. Conclusion Podophyllotoxin was well tolerated and had a good cure rate.

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