ORIGINAL ARTICLE |
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Year : 2014 | Volume
: 27
| Issue : 4 | Page : 677-682 |
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Comparative study of the effect of high-flux versus low-flux dialysis membranes on metabolic abnormalities in chronic hemodialysis patients
Ahmed Rabie El Arbagy1, Mahmoud Abd El Aziz Koura1, Hany Said El Barbary1, Abd El Samad Sobhy Abou El Nasr MBBCh 2
1 Department of Internal Medicine, Faculty of Medicine, Menoufiya University, Al-Menoufiya, Egypt 2 Department of Nephrology, Benha Teaching Hospital, Benha, Egypt
Correspondence Address:
Abd El Samad Sobhy Abou El Nasr Garawan, El Bagour, Al-Menoufia Egypt
Source of Support: None, Conflict of Interest: None | Check |
DOI: 10.4103/1110-2098.149667
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Objective
The aim of the study was to compare the effect of permeability of low-flux versus high-flux dialysis membranes on control of metabolic abnormalities in chronic hemodialysis patients.
Background
End-stage renal disease is associated with multiple physiological and metabolic disturbances, including hypertension, anemia, hyperparathyroidism, dyslipidemia, malnutrition, and other serious problems that markedly and negatively affect prognosis and the quality of life of uremic patients. New dialyzers have large pores and they are more compatible than pure cellulose membranes; thus, they provoke less inflammatory reaction and are more efficient in removal of uremic toxins.
Materials and methods
Forty adult patients on regular hemodialysis were enrolled in a prospective study. Low-flux polysulfone membranes were used for at least 6 months and then patients were switched to use high-flux polysulfone membranes for 1 month. Serum electrolytes and intact parathyroid hormone (PTH) before and after dialysis were compared before and after changes in dialysis membrane.
Results
At the end of the 1-month use of high-flux filters, a highly significant increase in the mean of hemoglobin levels from 9.50 ± 1.08 to 10.29 ± 1.04 (P = 0.001) was evident. Postdialysis mean arterial blood pressure decreased significantly after use of high-flux dialysis (P = 0.002). There were highly significant decreases in predialysis blood urea nitrogen, phosphorus, sodium, and potassium after the use of high-flux filters. Predialysis intact PTH level (415.96 ± 226.72 ng/dl) showed a significant decline (P < 0.05) compared with the predialysis intact PTH (312.28 ± 191.98 ng/dl) with low-flux membranes.
Conclusion
High-flux dialysis membranes are more efficient in control of metabolic abnormalities in chronic hemodialysis patients than low-flux membranes. |
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