ORIGINAL ARTICLE |
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Year : 2014 | Volume
: 27
| Issue : 3 | Page : 507-513 |
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Evaluation of β-catenin expression in muscle-invasive urothelial bladder carcinoma
Fatma Ahmed Elserafy1, Tarek Mohamed Abdel Elbaky1, Eid Abdel-Rasoul Elsherif1, Noha Mohamed Nor-Eldin-Elkady2, Marwa Mohamed Dawood2, Mohamed Sayed El Gharabawy1
1 Department of Urology, Faculty of Medicine, Menoufia University, Menoufia, Egypt 2 Department of Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
Correspondence Address:
MSc Mohamed Sayed El Gharabawy Urology Department, Faculty of Medicine, Menoufia University, Menoufia Egypt
Source of Support: None, Conflict of Interest: None | Check |
DOI: 10.4103/1110-2098.145491
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Objectives
This study aimed at evaluation of the expression of β-catenin in muscle-invasive urothelial bladder carcinoma and its correlation with other clinicopathological parameters of prognostic importance.
Background
β-Catenin is a protein that is encoded by the CTNNB1 gene that can function as an oncogene. Activation of the Wnt/β-catenin signaling pathway by aberrant accumulation of stabilized β-catenin contributes to the progression of several human cancers. Therefore, inhibition of the Wnt pathway may have a major therapeutic potential.
Patients and methods
This study was conducted as a retrospective study at Urology and Pathology Departments, Faculty of Medicine, Menoufia University, during the period between May 2011 and May 2013. A total of 40 patients were included and divided into two groups. The first one included 10 patients with chronic nonspecific cystitis as a control group and the second one included 30 patients with muscle-invasive urothelial bladder carcinoma who underwent radical cystectomy. The pathological blocks of both groups were investigated for the expression of β-catenin using immunohistochemical staining.
Results
β-Catenin expression was noticed in 100% (30 cases) of muscle-invasive bladder carcinoma and in 70% (seven cases) of nonmalignant cases. In the malignant group, 26 (87%) cases showed nucleocytoplasmic expression and four (13%) cases showed membranous expression only. There was a significant correlation between nucleocytoplasmic localization of β-catenin and some pathological parameters such as tumor grade, stage, and mitosis. Furthermore, the study showed statistically significant correlation between intensity of β-catenin expression and tumor grade, stage, lymph node metastasis, vascular and perineural invasion, mitosis, and microvessel density.
Conclusion
Nucleocytoplasmic expression of β-catenin and high intensity of its expression was associated with poor prognostic parameters. |
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