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Figure 5: Electron micrographs of kidney sections of control group (a and b), of CRF induced group (c and d): (a)- Part of a distal convoluted tubule. Its cell lining shows a nucleus (n) which is apical, oval and euchromatic with a central heterochromatic nucleolus. Apical electron-lucent cytoplasm can be noticed (thin arrow) with no microvilli. Numerous basal elongated mitochondria can be seen (notched arrow). (x5000). (b)- A cell of a distal convoluted tubule. The cell rests on an even basal lamina with unremarkable basal infoldings or striations (notched arrow). The mitochondria appear elongated and parallel to each other and perpendicular to the longitudinal axis of the cell (arrow). Notice: the euchromatic oval nucleus (n) with a central nucleolus. (x12000). (c)- A part of a distal convoluted tubule showing the lining epithelial cells with scanty organelles, the mitochondria show decreased number and size (curved arrow). The cells show loss of their nuclei (asterisks). There is an extruded cell into the tubular lumen (thin arrow) (x5000). (d)- Part of the epithelial cell lining of a distal convoluted tubule. One of its nuclei shows apoptotic changes. The nucleus is fragmented (notched red arrow). An apoptotic body can be seen including the fragmented part of the nucleus and other organelles (arrow). Another apoptotic bud is being formed (a). A ghost cell can be noticed with vanished organelles (g) (x12000). |
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