Figure 1: Photomicrographs of H and E stained kidney sections of the control group (a-c) and of the CRF induced group (d-f): (a)- The renal tissue consisting of an outer dense region which appears dark and granular, the cortex (c), it lies beneath the renal capsule (arrow) and an inner pale region, the medulla (m) (H and E, x40). (b)The renal cortex (c) which shows sparse globular masses, the renal corpuscles (arrows) and different sizes of renal tubules (arrow heads). The medulla (m) consists of collecting tubules with thin wall and wide lumen (notched arrow) (H and E, x100). (c)- The renal corpuscles (thick arrows) and renal tubules of two shapes, rounded (thin arrows) and elongated ones (notched arrows) (H and E, x200). (d)The renal cortex with distorted architecture. Diffuse empty spaces can be seen (thin arrows). Accumulation of peritubular inflammatory cells can be observed (thick arrows). Notice: the medulla with dilated collecting tubules (asterisk) (H and E, x40). (e)- The renal cortex with extensive areas of hemorrhage (thick arrows). Thick wall congested blood vessel can be noticed (notched arrow). Hyalinization of the renal tubules can be seen (thin arrows) (H and E, x100). (f)Shrunken and condensed glomerular capillary tuft (thin arrow) with widening of the Bowman's space (asterisks). A DCT appears extensively dilated with compression and thing of its wall (curved arrow). Notice: the hyalinization of the renal tubules most likely the PCTs (thick arrows) and the thick wall congested blood vessel (notched arrow). (H and E, x200).