Year : 2019 | Volume
: 32 | Issue : 1 | Page : 8--13
Immunotherapy for advanced bladder cancer: a new era
Eman Abd ElRazek, Suzan Alhassanin, Hagar Al Agizy, Alshimaa M Alhanafy, Eman Helmy Desoky
Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine-Menoufiya University, Menoufia, Egypt
The aim of this study was to analyze data and current trends in immune checkpoint targeting therapy for bladder cancer.
A systematic literature search was performed for clinical trials in the Medline databases (Google Scholar, ClinicalTrials.gov, Cochrane, http://www.ekb.eg) and all materials available in the Internet from 2014 up to 2017 according to Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines.
The initial search yielded 35 articles, of which 30 fulfilled the inclusion criteria. The articles studied the role of Immune checkpoint targeting therapy in bladder cancer.
If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment included whether ethical approval was obtained, eligibility criteria specified, appropriate controls, adequate information, and defined assessment measures.
Comparisons were made by structured review, with the results tabulated.
Humanized monoclonal antibodies that block CTLA-4 (ipilimumab, tremelimumab), PD-1 (nivolumab, pembrolizumab), or PD-L1 (atezolizumab, durvalumab, avelumab) have all shown antitumor activity in patients with urothelial carcinoma (UC). Atezolizumab and nivolumab are approved by the Food and Drug Administration for second-line therapy for advanced UC and a number of other checkpoint inhibitors are in clinical trials.
Immunotherapy for UC remains a promising and active area of research; intravesical Bacillus Calmette-Guerin has been used as a form of immunotherapy in nonmuscle invasive disease. Also, numerous agents, particularly the monoclonal antibodies targeting checkpoint inhibition pathways, are showing encouraging signs of clinical activity.
Eman Helmy Desoky
8- El Teraa Street, Sector-2, Birket EL Saba City, Menoufiagovernate, 32717
|How to cite this article:|
ElRazek EA, Alhassanin S, Al Agizy H, Alhanafy AM, Desoky EH. Immunotherapy for advanced bladder cancer: a new era.Menoufia Med J 2019;32:8-13
|How to cite this URL:|
ElRazek EA, Alhassanin S, Al Agizy H, Alhanafy AM, Desoky EH. Immunotherapy for advanced bladder cancer: a new era. Menoufia Med J [serial online] 2019 [cited 2019 Aug 20 ];32:8-13
Available from: http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2019;volume=32;issue=1;spage=8;epage=13;aulast=ElRazek;type=0