Menoufia Medical Journal

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 32  |  Issue : 1  |  Page : 194--197

Study of serum YKL-40 level in patients with chronic obstructive pulmonary disease


Nourane Y Azab1, Ahmed A Khames1, Maha Yousif1, Ibrahim S El Madbouh2, Doaa S Fouda3 
1 Department of Chest, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Biochemistry, Faculty of Medicine, Menoufia University, Menoufia, Egypt
3 Al Mehalla Chest Hospital, Al Mehalla, Egypt

Correspondence Address:
Doaa S Fouda
Samanoud, Gharbia
Egypt

Objective The aim of the paper was to investigate the relationship between serum YKL-40 levels and severity of chronic obstructive pulmonary disease (COPD). Background COPD is a major health problem with increasing morbidity and mortality throughout the world. A newly recognized biomarker, YKL-40, is a chitin-binding glycoprotein, and its serum level is elevated in inflammatory diseases. However, it has not been thoroughly investigated in COPD. Patients and methods A total of 30 patients with stable COPD and 10 healthy individuals as a control group were enrolled for estimation of modified Medical Research Counseling dyspnea scale, spirometry, and serum YKL-40 levels. Results Serum YKL-40 level was increased significantly in patients with COPD compared with healthy controls. There was a positive correlation between serum YKL-40 level and each of modified Medical Research Counseling dyspnea scale severity and age, and a negative correlation with forced expiratory volume in the first second percent of predicted. Conclusion High serum YKL-40 levels were correlated with severity of COPD.


How to cite this article:
Azab NY, Khames AA, Yousif M, El Madbouh IS, Fouda DS. Study of serum YKL-40 level in patients with chronic obstructive pulmonary disease.Menoufia Med J 2019;32:194-197


How to cite this URL:
Azab NY, Khames AA, Yousif M, El Madbouh IS, Fouda DS. Study of serum YKL-40 level in patients with chronic obstructive pulmonary disease. Menoufia Med J [serial online] 2019 [cited 2019 Jun 16 ];32:194-197
Available from: http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2019;volume=32;issue=1;spage=194;epage=197;aulast=Azab;type=0