Menoufia Medical Journal

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 30  |  Issue : 1  |  Page : 190--195

Plasma vitamin C concentration in chronic kidney disease: Comparison between diabetic and nondiabetic patients


Nabil A Elkafrawy1, Alaa Eldine A Dawood1, Mohammed S Rizk2, Saad M Mohammed Elgengaihy3 
1 Department of Internal Medicine, Faculty of Medicine, Menoufia University, Shibin Al Kom, Egypt
2 Department of Microbiology, Faculty of Medicine, Menoufia University, Shibin Al Kom, Egypt
3 Department of Nephrology, Alamrya General Hospital, Alexandria, Egypt

Correspondence Address:
Saad M Mohammed Elgengaihy
Tanta, Gharbia, 31511
Egypt

Objective The aim of the study is to evaluate the relationship between renal functions and plasma vitamin C concentration in nondiabetic and diabetic patients with chronic kidney disease. Background A decreased plasma level of vitamin C has been reported to be associated with an increased risk of cardiovascular morbidity and mortality. Here, we sought to determine the vitamin C status of patients with chronic kidney disease and the pathophysiological role of vitamin C in these patients. Patients and methods A total of 50 patients were included in the study and classified into two groups: group I, patients with chronic kidney disease with diabetes and group II, patients with chronic kidney disease without diabetes. The relationship between renal function and plasma vitamin C concentration was evaluated, as well as the effect of diabetes on this relationship. Results Statistical comparison revealed a significant statistical increase in the mean value of vitamin C level in the group II compared with group I (P ≤ 0.001). Also, there was a significant positive correlation between vitamin C level and both weight and estimated glomerular filtration rate in the patients, whereas there was a significant negative correlation between vitamin C level and each of serum creatinine level, blood urea level, albumin–creatinine ratio, and glycosylated hemoglobin level in the patients. Conclusion Renal dysfunction was associated with a decreased level of plasma vitamin C in patients with chronic kidney disease. Diabetic patients showed a lower level of vitamin C at any given estimated glomerular filtration rate compared with nondiabetic patients.


How to cite this article:
Elkafrawy NA, Dawood AA, Rizk MS, Mohammed Elgengaihy SM. Plasma vitamin C concentration in chronic kidney disease: Comparison between diabetic and nondiabetic patients.Menoufia Med J 2017;30:190-195


How to cite this URL:
Elkafrawy NA, Dawood AA, Rizk MS, Mohammed Elgengaihy SM. Plasma vitamin C concentration in chronic kidney disease: Comparison between diabetic and nondiabetic patients. Menoufia Med J [serial online] 2017 [cited 2024 Mar 28 ];30:190-195
Available from: http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2017;volume=30;issue=1;spage=190;epage=195;aulast=Elkafrawy;type=0