Year : 2017 | Volume
: 30 | Issue : 1 | Page : 162--167
Prolactin contributes to the pathogenesis of thrombocytopenia in patients with hepatitis C virus
Ali Z Glal1, Sabry A Shoeib1, Mohammed A Abdelhafez1, Nahla F Osman2, Waleed S Eldin1, Alaa E Abdelsala1, Walaa M Elgheriany1
1 Department of Internal medicine, Faculty of Medicine, Menofia University, Menofia, Egypt
2 Department of Clinical Pathology, Faculty of Medicine, Menofia University, Menofia, Egypt
The aim of this work was to explore the role prolactin (PRL) in hepatitis C (HCV)-related thrombocytopenia.
PRL is involved in the activation of a number of immunological responses. It enhances the progression of the immune process in autoimmune diseases. Autoimmunity is a common finding in chronic hepatitis C, and a significant association between hyperprolactinemia (HPRL) and infection with HCV genotype 4 has been reported.
Materials and methods
This study was carried at the Internal Medicine Department, Menoufia University Hospital, in the period between May 2014 and December 2014. Three groups were involved: group I, which included 41 chronic hepatitis C patients with thrombocytopenia; group II, which included 35 chronic hepatitis C patients without thrombocytopenia; and group III, which included 25 healthy individuals with matched age and sex.
Patients with HCV-related thrombocytopenia had HPRL and their serum PRL levels were significantly higher compared with HCV patients with normal platelet count and compared with normal controls (P = 0.02 and 0.001, respectively). We demonstrated negative correlation between HPRL and platelet count (r = 0.32 and P = 0.04). In addition, there was a significant difference in platelet count among different stages of liver fibrosis as the platelet count dropped steadily in line with the stage of fibrosis (P = 0.004).
This study shows that HPRL is present in a subset of patients with HCV-related thrombocytopenia and can be a contributing factor in the pathogenesis of thrombocytopenia in those patients. Thus, anti-PRL may be a treatment option in this category of patients.
Walaa M Elgheriany
Department of Internal Medicine, Faculty of Medicine, Menoufia University, Shebin Al-Kom, Menoufia, 32843
|How to cite this article:|
Glal AZ, Shoeib SA, Abdelhafez MA, Osman NF, Eldin WS, Abdelsala AE, Elgheriany WM. Prolactin contributes to the pathogenesis of thrombocytopenia in patients with hepatitis C virus.Menoufia Med J 2017;30:162-167
|How to cite this URL:|
Glal AZ, Shoeib SA, Abdelhafez MA, Osman NF, Eldin WS, Abdelsala AE, Elgheriany WM. Prolactin contributes to the pathogenesis of thrombocytopenia in patients with hepatitis C virus. Menoufia Med J [serial online] 2017 [cited 2020 Oct 26 ];30:162-167
Available from: http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2017;volume=30;issue=1;spage=162;epage=167;aulast=Glal;type=0