TY - JOUR
A1 - Farag, Azza
A1 - Sharaky, Dalia
A1 - El-Shafey, Eman
A1 - Allam, Sawsan
T1 - Tissue expression of endothelial selectin in patients with atopic dermatitis
Y1 - 2020/7/1
JF - Menoufia Medical Journal
JO - Menoufia Med J
SP - 1041
EP - 1044
VL - 33
IS - 3
UR - http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2020;volume=33;issue=3;spage=1041;epage=1044;aulast=Farag
DO - 10.4103/mmj.mmj_72_19
N2 -
Objective
To investigate the role of endothelial selectin (E-selectin) in atopic dermatitis (AD) through evaluation of the immunohistochemical expressions in lesional skin biopsies.
Background
AD is a chronic, pruritic inflammatory skin disease that occurs most frequently in children. In AD, the inflammatory cascade is initiated by the release of proinflammatory cytokines from atopic keratinocytes.
Patients and methods
A total of 50 patients with AD and 10 healthy control participants were included in this case–control study. From all participants, skin biopsies were taken, and immunohistochemical staining by E-selectin monoclonal antibodies was done.
Results
There were significant elevations in E-selectin cellular localization (P = 0.01) as well as dermal inflammatory infiltrates in AD cases than controls.
Conclusion
E-selectin participates in AD pathogenesis.
ER -