TY - JOUR A1 - Farag, Azza A1 - Sharaky, Dalia A1 - El-Shafey, Eman A1 - Allam, Sawsan T1 - Tissue expression of endothelial selectin in patients with atopic dermatitis Y1 - 2020/7/1 JF - Menoufia Medical Journal JO - Menoufia Med J SP - 1041 EP - 1044 VL - 33 IS - 3 UR - http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2020;volume=33;issue=3;spage=1041;epage=1044;aulast=Farag DO - 10.4103/mmj.mmj_72_19 N2 - Objective To investigate the role of endothelial selectin (E-selectin) in atopic dermatitis (AD) through evaluation of the immunohistochemical expressions in lesional skin biopsies. Background AD is a chronic, pruritic inflammatory skin disease that occurs most frequently in children. In AD, the inflammatory cascade is initiated by the release of proinflammatory cytokines from atopic keratinocytes. Patients and methods A total of 50 patients with AD and 10 healthy control participants were included in this case–control study. From all participants, skin biopsies were taken, and immunohistochemical staining by E-selectin monoclonal antibodies was done. Results There were significant elevations in E-selectin cellular localization (P = 0.01) as well as dermal inflammatory infiltrates in AD cases than controls. Conclusion E-selectin participates in AD pathogenesis. ER -