%A Farag, Azza
%A Sharaky, Dalia
%A El-Shafey, Eman
%A Allam, Sawsan
%T Tissue expression of endothelial selectin in patients with atopic dermatitis
%9 Original Article
%D 2020
%J Menoufia Medical Journal
%R 10.4103/mmj.mmj_72_19
%P 1041-1044
%V 33
%N 3
%U http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2020;volume=33;issue=3;spage=1041;epage=1044;aulast=Farag
%8 July 1, 2020
%X
Objective
To investigate the role of endothelial selectin (E-selectin) in atopic dermatitis (AD) through evaluation of the immunohistochemical expressions in lesional skin biopsies.
Background
AD is a chronic, pruritic inflammatory skin disease that occurs most frequently in children. In AD, the inflammatory cascade is initiated by the release of proinflammatory cytokines from atopic keratinocytes.
Patients and methods
A total of 50 patients with AD and 10 healthy control participants were included in this case–control study. From all participants, skin biopsies were taken, and immunohistochemical staining by E-selectin monoclonal antibodies was done.
Results
There were significant elevations in E-selectin cellular localization (P = 0.01) as well as dermal inflammatory infiltrates in AD cases than controls.
Conclusion
E-selectin participates in AD pathogenesis.
%0 Journal Article
%I Wolters Kluwer Medknow Publications
%@ 1110-2098