RT - Journal
TY - JOUR
A1 - Abdel Hamid, Ahmed
A1 - Abd El-Gayed, Alaa
A1 - Saif-Elnasr, Ibarhim
A1 - Soliman, Mohamed
T1 - Comparison the efficacy and safety between Insulin and Metformin in gestational diabetes mellitus management
YR - 2019/10/1
JF - Menoufia Medical Journal
JO - Menoufia Med J
SP - 1376
OP - 1381
VO - 32
IS - 4
UL - http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2019;volume=32;issue=4;spage=1376;epage=1381;aulast=Abdel;t=5
DO - 10.4103/mmj.mmj_303_18
N2 - Objective
The objective of this study was to evaluate the efficacy and safety between insulin and metformin in the management of gestational diabetes mellitus (GDM).
Background
GDM is a common complication of pregnancy. Blood glucose control improves perinatal outcomes. Medical nutrition therapy is the milestone management.
Patients and methods
In a prospective randomized comparative study, 240 antenatal women whose pregnancies had been complicated by GDM and did not respond to diet alone were recruited from antenatal clinics at the Obstetrics Department in Menofia University Hospitals and Shebin El-Kom Teaching Hospital from November 2016 to March 2018. They were divided randomly into two groups; 120 patients in each group were subjected to either insulin or metformin medications. Outcomes were comparing the effects of medications on maternal glycemic control, maternal complications and neonatal outcome.
Results
There was no significant difference in controlling high blood sugar in GDM with the use of insulin or metformin. Maternal complications in both groups had no significant difference, and fetal outcomes were as well similar.
Conclusion
Glycemic control in GDM can be achieved by using metformin orally without increasing the risk for maternal complications with a satisfying neonatal outcome.
ER -