AU - Azab, Nourane AU - Khames, Ahmed AU - Yousif, Maha AU - El Madbouh, Ibrahim AU - Fouda, Doaa TI - Study of serum YKL-40 level in patients with chronic obstructive pulmonary disease PT - ORIG DP - 2019 Jan 1 TA - Menoufia Medical Journal PG - 194-197 VI - 32 IP - 1 4099- http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2019;volume=32;issue=1;spage=194;epage=197;aulast=Azab;type=0 4100- http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2019;volume=32;issue=1;spage=194;epage=197;aulast=Azab AB - Objective The aim of the paper was to investigate the relationship between serum YKL-40 levels and severity of chronic obstructive pulmonary disease (COPD). Background COPD is a major health problem with increasing morbidity and mortality throughout the world. A newly recognized biomarker, YKL-40, is a chitin-binding glycoprotein, and its serum level is elevated in inflammatory diseases. However, it has not been thoroughly investigated in COPD. Patients and methods A total of 30 patients with stable COPD and 10 healthy individuals as a control group were enrolled for estimation of modified Medical Research Counseling dyspnea scale, spirometry, and serum YKL-40 levels. Results Serum YKL-40 level was increased significantly in patients with COPD compared with healthy controls. There was a positive correlation between serum YKL-40 level and each of modified Medical Research Counseling dyspnea scale severity and age, and a negative correlation with forced expiratory volume in the first second percent of predicted. Conclusion High serum YKL-40 levels were correlated with severity of COPD.