TY - JOUR
A1 - El-Hamid Saleh, Sohair
A1 - Youssef, Gergess
A1 - El-Samea Aiad, Hayam
A1 - Al-Kotb, Safaa
A1 - Donia, Sally
A1 - El-Domiaty, Heba
T1 - Effect of quercetin treatment on hyperuricemic renal dysfunctions and hemodynamic parameters
Y1 - 2017/10/1
JF - Menoufia Medical Journal
JO - Menoufia Med J
SP - 978
EP - 983
VL - 30
IS - 4
UR - http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2017;volume=30;issue=4;spage=978;epage=983;aulast=El-Hamid
DO - 10.4103/mmj.mmj_220_17
N2 -
Objective
The aim of this study was to assess the potential effect of quercetin treatment on hyperuricemic renal dysfunctions and hemodynamic changes in in vivo and in vitro published studies.
Materials and methods
Data were obtained from Medline databases (PubMed, Medscape, ScienceDirect.) and all materials available in the internet from 2001 to 2016. The initial search presented 170 articles, of which 47 met the inclusion criteria. The articles studied the effect of quercetin treatment on hyperuricemic renal dysfunctions and hemodynamic changes. If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment included whether ethical approval was gained, eligibility criteria specified, appropriate controls, adequate information, and defined assessment measures. Comparisons were made using structured review with the results tabulated.
Findings
In total 47 potentially relevant publications were included. There was an association between hyperuricemia and renal function impairment together with deterioration of hemodynamic parameters. This association was due to hyperuricemic vascular endothelial dysfunction and oxidative stress. Studies concerned with quercetin treatment found that quercetin was able to improve hyperuricemic renal functions and hemodynamic parameter mainly due to its antioxidant effect.
Conclusion
Quercetin treatment improved hyperuricemic renal dysfunctions and hemodynamic parameters.
ER -