TY - JOUR
A1 - El-Edel, Rawhia
A1 - Mostafa, Mohamed
A1 - Montaser, Belal
A1 - El-Hag Ali, Yasmen
T1 - Study of Apa-I vitamin D receptor gene polymorphism in patients with hepatocellular carcinoma
Y1 - 2017/4/1
JF - Menoufia Medical Journal
JO - Menoufia Med J
SP - 619
EP - 625
VL - 30
IS - 2
UR - http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2017;volume=30;issue=2;spage=619;epage=625;aulast=El-Edel
DO - 10.4103/mmj.mmj_673_16
N2 - Objective
The aim of this study is to study vita min D receptor (VDR) Apa-I gene polymorphism in patients with hepatocellular carcinoma (HCC) infected with chronic hepatitis C.
Background
HCC is a global problem. In Egypt, it is one of the major health problems facing the health authorities. Several major risk factors of HCC have been identified, including chronic infection of hepatitis B virus and hepatitis C virus. Nevertheless, only a fraction of infected patients develop HCC during their lifetime suggesting that genetic factors might modulate HCC development. Consequently, identification of additional genetic factors affecting transcription of specific regulatory genes could help to select high-risk populations.
Patients and methods
This study was conducted on 120 patients between February 2015 and February 2016: 40 patients with HCC and 40 patients with liver cirrhosis without any radiological evidence of HCC, who presented to the Hepatology Department, National Liver Institute, Menoufia University, along with 40 age-matched and sex-matched healthy controls. Vitamin D receptor Apa-I gene polymorphism was determined by PCR-restriction fragment length polymorphism.
Results
Our study revealed significant statistical difference between patients with HCC and those with liver cirrhosis also between patients with HCC and control group regarding VDR gene Apa-I polymorphism. In HCC group, there was also significant statistical difference between the studied Apa-I VDR genotypes and α-fetoprotein, tumor size, and serum albumin.
Conclusion
VDR Apa-I gene polymorphism could be associated with increased risk of HCC development in chronic hepatitis C virus-infected patients.
ER -