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ORIGINAL ARTICLE
Year : 2019  |  Volume : 32  |  Issue : 1  |  Page : 352-358

Therapeutic effects of human stem cells in experimentally induced acute kidney injury in rats


1 Department of Internal Medicine, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Clinical Physiology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
3 Department of Internal Medicine, Ashmoun Central Hospital, Menoufia, Egypt

Correspondence Address:
Hussain M Hussain Kholaif
Ashmoun 24582, Menoufia Governorate
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_530_17

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Objective The aim of this study was to evaluate the effect of stem cell therapy in drug-induced acute kidney injury in rats. Background Acute kidney injury (AKI) is defined as a rapid decrease in renal functions within few days; thus drug-induced AKI is a frequent entity in clinical medicine. Stem cell therapy provides a hopeful prospective for injured tissues and for repairing damaged organs. Materials and methods A total of 30 male Swiss albino rats were used in the present study. The animals were randomly divided into three groups. Group I: control group (10 rats). Group II: AKI group (10 rats), gentamicin-induced AKI rat models were used. Group III: stem-cell-treated AKI group (10 rats). Rats with established AKI were injected with CD34-positive stem cells. The three studied groups were assessed for serum urea, blood urea nitrogen, serum creatinine, and kidney injury molecule 1 (KIM-1). At the end, all the rats were killed and their kidneys were excised for histopathology and immunohistochemical studies. Results Serum KIM-1 level was significantly higher in the AKI group in comparison with both control group and stem-cell-treated group (P = 0.001), whereas no statistically significant difference was found between control group and stem-cell-treated group regarding serum KIM-1 level (P = 0.755). The results of the immunohistopathological studies have shown no significant changes between control group and AKI-stem-cell-treated group. Conclusion This study showed that AKI markers improved after treatment by stem cells in AKI-induced group.


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