Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2019  |  Volume : 32  |  Issue : 1  |  Page : 311-316

Effect of omega-3 on tumor necrosis factor-α in children on hemodialysis


1 Pediatrics Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt
2 Clinical Pathology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt
3 Pediatric Department, Shebin El-Kom Teaching Hospital, Shebin El-Kom, Egypt

Correspondence Address:
Eman H Dawood
Pediatric Department, Shebin El-Kom Teaching Hospital, Shebin El-Kom, Menoufia
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_475_17

Rights and Permissions

Objectives The aim of this study was to assess the effect of high-dose omega-3 supplementation on tumor necrosis factor-α (TNF-α) in children on long-term hemodialysis. Background Patients who are on hemodialysis have elevated serum levels of inflammatory markers. Giving high doses of omega-3 supplementation results in significant decrease in TNF-α (one of the inflammatory markers). Patients and methods This study was conducted at a pediatric dialysis unit in Menoufia University hospital, and included 26 patients from January 2015 to April 2015. The study commenced after approval of the local institutional ethical committee of Menoufia University hospital and obtaining written consents from all the participants in our study. Results The mean age of the 26 patients was 13.4 years (range: 8–17 years). There were 13 (50%) males and (50%) females. The comparison of the studied variables before and after supplementation with omega-3 fatty acids showed that there were statistically high significant differences between the level of TNF-α before (147.62 ± 13.57 mg/dl) and after (79.73 ± 16.884 mg/dl) supplementation with omega-3 fatty acid (P < 0.001). Conclusion The use of omega-3 caused significant decrease in serum levels of TNF-α in children on hemodialysis, and omega-3 may need to be taken in larger doses to exert its anti-inflammatory effect.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed65    
    Printed1    
    Emailed0    
    PDF Downloaded9    
    Comments [Add]    

Recommend this journal