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ORIGINAL ARTICLE
Year : 2019  |  Volume : 32  |  Issue : 1  |  Page : 275-281

Cytochrome p450-2J2 gene polymorphism in patients with coronary artery disease


1 Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Shebein El Kom, Menoufia Governorate, Egypt
2 Department of Biochemistry, National Liver Institute, Menoufia University, Shebein El Kom, Menoufia Governorate, Egypt
3 Department of Cardiology, Faculty of Medicine, Menoufia University, Shebein El Kom, Menoufia Governorate, Egypt

Correspondence Address:
Aliaa A El Feshawy
Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Shebein El Kom, Menoufia Governorate
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_584_17

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Objective The objective of this study was to study the CYP2J2 gene polymorphism in patients with coronary artery disease (CAD). Background Cytochrome P450 (CYP) 2J2 is expressed in the vascular endothelium and metabolizes arachidonic acid to epoxyeicosatrienoic acids. Epoxyeicosatrienoic acids are vasodilators and inhibitors of vascular inflammation. Patients and methods This case–control study was carried on 80 participants; 55 of them had CAD and 25 control participants had no coronary artery stenosis. They were selected from Cardiac Catheterization Laboratory of Menoufia University Hospital from November 2015 to March 2017. They underwent a full history, clinical examination, ECG, random blood glucose level, lipid profile (triglycerides, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol), and CYP2J2 polymorphism assessment by real-time PCR assay. Results The CYP2J2 genotype, alleles, and the dominant model (CC vs. CT + TT) distributions of single-nucleotide polymorphism (rs2280275) showed a significant difference between patient and control groups for total participants and males (for genotype: P < 0.001; for allele: P < 0.001; for dominant model: P < 0.001 respectively). The multiple logistic regression analysis for total participants and males showed that those who had either TT or CT were 1.08 and 1.09 times, respectively, to have CAD. The CYP2J2 genotype, alleles, and the dominant model distributions showed a significant difference between the two vessel groups (for genotype: P = 0.032; for allele: P = 0.007; for dominant model: P = 0.029). Conclusion The obtained results suggested that CYP2J2 polymorphism was associated with an increased risk of CAD.


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