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Year : 2019  |  Volume : 32  |  Issue : 1  |  Page : 255-260

Association of HLA-G gene polymorphism with hepatocellular carcinoma in Egyptian population

1 Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Clinical Pathology, National Liver Institute, Menoufia University, Menoufia, Egypt

Correspondence Address:
Mai I Elashmawy
Department of Clinical Pathology, National Liver Institute, Menoufia University, Shebein El Kom, Menoufia Governorate
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mmj.mmj_293_17

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Objective The aim of this work was to study the association of human leukocyte antigen-G (HLA-G) gene polymorphism with hepatocellular carcinoma (HCC) in Egyptian population. Background HCC represents an international public health concern as one of the most common and deadly cancers worldwide. It is the third most common cause of cancer-related death worldwide. In Egypt, HCC is the second most common cancer among men and the sixth most common cancer among women. In most cases, HCC develops within an established background of chronic liver disease (70–90% of all patients). The worldwide heterogeneous incidence reflects variations in the main risk factors, which include cirrhosis, chronic infection of hepatitis B virus and hepatitis C virus, aflatoxin, exposure to pesticide, and genetic host factors. Patients and methods This study was conducted on 100 participants: 40 patients with HCC, 40 patients with chronic hepatitis C with no radiological evidence of HCC who presented to the Hepatology Department, National Liver Institute, Menoufia University, and 20 age-matched and sex-matched healthy control group during the period between February 2015 and February 2016. HLA-G gene polymorphism was determined using PCR. Results Our study revealed no statistical difference between patients with HCC and those with chronic hepatitis C, nor between patients with HCC and the control group as regards HLA-G gene polymorphism. Conclusion HLA-G gene polymorphism is not associated with an increased risk for HCC development.

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