Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2018  |  Volume : 31  |  Issue : 2  |  Page : 417-428

Study of L1 cell adhesion molecule in patients with hepatocellular carcinoma


1 Department of Internal Medicine, Faculty of Medicine, Menoufia University, Shebin Al-Kom, Egypt
2 Department of Surgery, National Liver Institute, Menoufia University, Shebin Al-Kom, Egypt
3 Department of Pathology, Faculty of Medicine, Menoufia University, Shebin Al-Kom, Egypt
4 Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Shebin Al-Kom, Egypt

Correspondence Address:
Ahmed E.A. Moustafa
Shebin Al-Kom, Menoufia Governorate 32511
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-2098.239738

Rights and Permissions

Objective The aim of this study was to investigate the presence of L1 cell adhesion molecule (L1CAM) in the serum and tissue of patients with hepatocellular carcinoma (HCC) and determine its efficacy in the detection of early HCC. Background HCC meets the criteria of a tumor that would benefit from a surveillance program, but the poor sensitivity and specificity of currently available tools have prevented the widespread implementation of surveillance. Patient and methods This study included 105 patients from Menoufia University Hospitals and National Liver Institute. They were classified into four groups: group I, the healthy control group (15 individuals); group II, which included patients with hepatitis C-related liver cirrhosis (45 patients); group III, which included patients with early HCC (25 patients); and group IV, which included patients with advanced HCC (20 patients). All patients were subjected to thorough history taking, complete physical examination, liver function tests, serum α-fetoprotein evaluation, and serum L1CAM evaluation. Two biopsies were obtained from each patient in group III, one from neoplastic tissue and another one from adjacent cirrhotic tissue to detect the expression of L1CAM by immunohistochemistry. Results The mean serum L1CAM level was highly significantly higher in both the early and advanced HCC groups than in all subgroups of liver cirrhosis. The expression of L1CAM was highly significantly higher in tumor tissues than in adjacent cirrhotic tissues. Conclusion This study suggests that L1CAM is accurate in differentiating patients with HCC even in early stage from those with nonmalignant chronic liver disease.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1661    
    Printed74    
    Emailed0    
    PDF Downloaded101    
    Comments [Add]    

Recommend this journal