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 Table of Contents  
ORIGINAL ARTICLE
Year : 2018  |  Volume : 31  |  Issue : 1  |  Page : 218-224

Comparing outcome of scalp tissue expansion for repairing postburn alopecia in adults versus children


1 Department of Plastic Surgery, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of General Surgery, Faculty of Medicine, Menoufia University, Menoufia, Egypt
3 Department of Plastic Surgery, Nasr City Insurance Hospital, Cairo, Egypt

Date of Submission28-Jan-2017
Date of Acceptance23-Apr-2017
Date of Web Publication14-Jun-2018

Correspondence Address:
Eman M Fathy
39 Al Mahata Street, Helwan, Cairo, 11722
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_710_16

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  Abstract 


Objective
The aim of this study was to compare the outcome of tissue expansion between adults and children.
Background
Postburn alopecia of the scalp is a huge surgical challenge. In 1957, Charles Neuman first described the use of gradual tension, leading to the expansion of skin by an inflatable balloon, buried subcutaneously above the ear. In 1975, both Radovan and Austad's group began working on soft-tissue expansion.
Patients and methods
This study included 40patients divided into two groups–groupA included 20 children aged 5–12years, and groupB included 20 adults aged 16–29years. All patients suffered from postburn scalp alopecia, reconstructed using tissue expanders, with volume capacity ranging from 100 to 550ml.
Results
Infection occurred in four adults and 10 children, exposed expander was found in three adults and eight children, exposed valve line was found in three adults and three children, and ischemia of the flap in one child.
Conclusion
Using tissue expanders is a reliable and safe method for reconstructing postburn alopecia with a very good outcome in adult patients compared with young children.

Keywords: alopecia, expansion complications, tissue expanders


How to cite this article:
Kishk T, El Sisi A, Hagag M, Fathy EM. Comparing outcome of scalp tissue expansion for repairing postburn alopecia in adults versus children. Menoufia Med J 2018;31:218-24

How to cite this URL:
Kishk T, El Sisi A, Hagag M, Fathy EM. Comparing outcome of scalp tissue expansion for repairing postburn alopecia in adults versus children. Menoufia Med J [serial online] 2018 [cited 2019 Jun 20];31:218-24. Available from: http://www.mmj.eg.net/text.asp?2018/31/1/218/234252




  Introduction Top


Scarring alopecia or cicatricial alopecia results from a follicular damage that is sufficient to produce destruction and replacement of the pilosebaceous structures by the scar fibrous tissue. Burn is an exogenous factor that causes secondary scarring alopecia [1]. Many techniques have been used for treating alopecia surgically, such as scalp reduction, hair grafting, the use of local flaps, and the use of tissue expanders [2].

Tissue expansion is an important tool for providing donor skin that is an optimal match in terms of skin color, texture, and hair-bearing characteristics [2]. This occurs by implanting a sac subcutaneously, and by regularly injecting normal saline into it new skin forms under the mechanical stretch, providing a supply of tissue similar in color, structure, and distribution to the lost tissues for defect repair [3].

There are factors to consider when planning a tissue expansion strategy: the dimensions of tissue to be replaced, proper expander selection, incision type and placement for expander insertion, the number of expanders to be used, and the schedule for saline injections. Careful planning is necessary to obtain excellent results [3]. Tissue expanders come in all shapes and sizes. Several investigators have recommended the use of expanders with a base width that is 2.5–3times the width of the defect to be covered. Injection of 10% of the volume per week is required to complete expansion within a 3-month period [4].

Once the expander has been successfully inflated and ready for removal, advancement or rotation of the flap is decided. The best method for maximizing the use of expanded tissue in both vertical and horizontal directions is by scoring the capsule to increase flap advancement. Measuring the dome of the expander and subtracting the width of the expander is fairly accurate in determining the amount of flap advancement [5].

All expanders nowadays have a remote valve. The greatest advantage of the remote valve and filling tube is to keep the injection point well away from the balloon, thereby avoiding any risks of balloon puncture while inflating the expander. Remote placement allows positioning at a place under the skin where it can be easily palpated [6].

Tissue expansion is a long, multistage process that requires careful planning; therefore, it is likely that some complications and unfavorable results occur during the course. Minor complications include issues related to hematomas and seromas, valve placement or location, exposure of the valve alone, and inadequacy of the expansion related to the defect/lesion. Major complications include cellulitis and closed infections, exposure of the expander balloon itself, deflation of the balloon, and ischemic necrosis of the overlying skin [6].

The aim of this study was to compare the rate of complications of tissue expansion in scalps between adults and children.


  Patients and Methods Top


This study was carried out at Menoufia University hospitals and Nasr City Insurance Hospital from April 2014 to July 2015. This study included 40patients who were divided into two groups–groupA included 20 children aged 5–12years and groupB included 20 adults aged 16–29years. All patients suffered from postburn scalp alopecia. Adetailed history was obtained from all patients. Acareful medical examination was carried out for all patients regarding donor site and area of alopecia; tissue expansion was performed for all cases using saline-filled tissue expanders with variable volumes. The study was approved by the Ethics Committee of Menoufia Faculty of Medicine, and informed consent was obtained from each patient or the guardian of each patient.

Operative technique

Following general anesthesia, broad-spectrum intravenous antibiotics were administered to all patients.

Expanders criteria

Rectangular, smooth-surface, silicone tissue expanders were used with volumes varying from 100 to 550ml, and were preoperatively prepared according to the size of the defect.

Patient positioning: patients were placed in either the supine position or in a position according tothe site of alopecia to be reconstructed(frontal, temporal, or occipital).

Disinfection: the operative field was disinfected with povidone–iodine, and toweled in a normal manner.

First stage: implantation of silicone tissue expander

Step 1: the incision was made adjacent to the lesion where it would be the leading edge of the advancement flap or it could even be within the lesion. The incision should be perpendicular to the expander to lessen the risk of wound dehiscence, and of 3–5cm length for dissection of a reasonably large pocket.

Step 2: the pocket is dissected bluntly, using smooth-ended scissors in a subcutaneous plane. We created a narrow tunnel for the valve, after ensuring good hemostasis. The plane of the dissection is usually the relatively avascular subgaleal plane[Figure 1].
Figure 1: Dissection of the subgaleal pocket.

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Step 3: the expander was removed out of its sterile packaging. It was carefully examined for integrity of the envelope; any folds were stretched out gently, and the joint of the balloon with the tubing and the tubing with the valve were carefully inspected. Amethod to ensure integrity is to fully immerse the expander, tubing, and valve in a bowl of normal saline and gently squeeze it to examine the presence of any escaping air bubbles. Once it is confirmed that there is no leakage, the excess air within the expander is removed by using a vein needle inserted into the valve dome.

Step 4: the device was positioned after removing air, and the valve was pushed into its tunnel. If there was any possibility of migration from its tunnel, it was fixed with sutures. The system was tested by injecting 30ml of saline through the valve[Figure2].
Figure 2: Introduction of the expander to the subgaleal pocket.

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Step 5: the incision was closed using silk or vicryl 3–0 over a suction drainage system that was removed within 24h before discharging the patient. Patients were prescribed prophylactic antibiotic therapy for 5days. Skin sutures were removed after 10days once good primary healing had occurred.

Second stage: tissue expansion

Serial expansion was started 2weeks after insertion, provided that the skin flaps were in good condition. The injection must not be painful, and the skin should not be discolored. We stopped filling when patients felt a stretching sensation, because skin expansions are usually comfortable. If there was any sign of hyperpressure, we removed some liquid. The filling process was continued at a rate of one or two sessions per week until enough soft tissue was obtained[Figure3].
Figure 3: A male patient (a) after expander implantation; (b) during the process of expansion; (c) after reaching desirable flap size; and (d) after covering the defect with expanded skin flap.

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After cleaning the expander placement area and valve placement area as for any aseptic procedure, the valve area was carefully palpated once again, and a vein needle was pierced through the skin perpendicularly into the dome of the injection valve. Using a 10 cm 3 syringe, gentle aspiration was first performed to ensure continuity of the system and smooth return of saline from the expander; next, further expansion of the balloon was performed with normal saline.

A chart was maintained, which recorded the expander size/volume and shape inserted, the location of placement on the body, amount of saline filled intraoperatively, and any special features encountered during placement.

The level of expansion at any particular session was decided by the following:

  1. Palpating the expanded dome and assessing whether it is still soft and pliable or tight and tense
  2. Assessing the skin for signs of continued blanching on pressure at multiple points and good capillary return on release of pressure
  3. Patient tolerance and any pain and discomfort such as feeling very tight signaled the end of expansion for that session.


All these factors were balanced, and fluid was added or withdrawn toward the end of expansion in each session.

The scalp vein needle was removed, and the prick point was kept under pressure for a minute until any point bleeding stopped. The point was dabbed with antiseptic ointment and covered with a sterile gauze piece or a band-aid for 24h.

The total volume achieved at each session was recorded in the expansion chart with remarks about problems seen or local signs encountered at each session.

Third stage: designing the flap and removing the expander

  1. Step 1: the incision for advancing the flap is usually at the border between the expander and the defect. This incision was carefully deepened to the capsule. The expander was then gently removed
  2. Step 2: the tunnel that led to the port site was then incised under direct vision with an electrocauter on coagulating current, along the length of the tunnel up to the area of the port; subsequently, blunt dissection was performed to expose the port, and finally the port was freed and removed
  3. Step 3: a trial advancement of the expanded flap across the lesion/defect was then made to assess the reach of the flap. If the flap appeared to be short, an incision was made with an electrocauter to divide the base of the capsule. If further release was necessary, parallel incisions were made carefully in the capsule in the axis of advancement
  4. Step 4: the lesion was excised, final preparation of the defect was carried out, and hemostasis was confirmed. The flap was then advanced as required
  5. Step 5: a suction drain is placed and removed after 24–48h. Skin closure was performed.


Postoperativley, very light dressing was applied to avoid impairment of flap vascularity. Prophylactic antibiotics and analgesics were administered for 5days. The sutures were removed 8–10days postoperatively.

The patients were followed-up at the outpatient clinic: patients were seen several times in the clinic for assessing flap viability, any signs of infection, hematoma or seroma, and hair growth in the new flap.

Statistical methodology

Data management and analysis

The collected data were revised, coded, tabulated, and introduced to a PC using statistical package for social science(SPSS 15.0.1 for Windows, 2001; SPSS Inc, Chicago, Illinois). Data were presented and suitable analyses were carried out according to the type of data obtained for each parameter.

Descriptive statistics

  1. Mean±SD, and ranges were used to represent parametric numerical data
  2. Medians and interquartile ranges were used to represent nonparametric numerical data
  3. Frequencies and percentages were used for non-numerical data.


Analytical statistics

  1. Student's t-test was used to assess the statistical significance of the difference between two study group mean
  2. The χ2-test was used to examine the relationship between two qualitative variables
  3. Fisher's exact test was used to examine the relationship between two qualitative variables when the expected count was less than 5 in more than 20% of cells.



  Results Top


This prospective study was conducted as a joint venture by the Department of Plastic Surgery at Menoufia University Hospital and Nasr City Insurance Hospital from 2014 to 2015. This study included 40patients who were divided into two groups–groupA included 20 children aged 5–12years, and groupB included 20 adults aged 16–29years(25males and 15females), as shown in [Table1].
Table 1: Comparison between studied groups with regard to sex distribution

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All patients suffered from postburn alopecia, reconstructed using tissue expanders, with volume capacity ranging from 100 to 550ml, as shown in [Table2].
Table 2: Expander volume among the studied sample of patients

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The present study aimed to compare adults and children regarding postoperative outcome. Infection was present in four(20%) adults and 10(50%) children, exposed expander was observed in three(15%) adults and eight(40%) children, exposed valve line in three(15%) adults and three(15%) children, and ischemia of the flap in one(5%) child, as shown in [Table3] and [Figure4] and [Figure5].
Table 3: Comparison between the studied groups regarding type of postoperative complications

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Figure 4: Postoperative expander valve exposure.

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Figure 5: Postoperative exposed expander.

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Complications increased in children with a percentage of 55% against 30% in the adult group, as shown in [Table4].
Table 4: Comparison between the studied groups regarding postoperative complications

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Burn duration, area of alopecia, fluid volume, and expander size were statistically nonsignificant in groupA showing early postoperative removal compared with groupB, as shown in [Table5].
Table 5: Comparison between the studied groups regarding burn duration, area of alopecia, expander volume, fluid volume, and expander size

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The adult group showed better recovery than children, as shown in [Table6].
Table 6: Comparison between the studied groups regarding recovery

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  Discussion Top


Skin expansion is one of the major developments in reconstructive surgery. The use of tissue expansion has been popularized among plastic surgeons, and has become the treatment method of choice for many congenital and acquired defects in a wide variety of diseases [3]. It is believed that an alopecia area involving 50% or more of the total scalp surface can be repaired using multistage or serial tissue expansion [7].

It is important that tissue at the donor site is of good quality, well-vascularised, and free of any bacterial infection. Selecting the expander is related to the size of the defect, the available donor site, and expected advancement of a hemispherical domed flap. There is an end point indication of expansion at any session as local pain, blanching, and high tissue tension. Thin skin in elderly patients or children should be expanded more carefully [6].

In this study, postburn alopecia patients were selected for analyzing postoperative complications. The total surface area of alopecia in the child group(groupA) ranged from 20 to 150 cm 2 compared with 20 to 80 cm 2 in the adult group(groupB). Although the total surface area of alopecia in children seems larger compared with adults, it is statistically insignificant.

In this study, in groupA, there was infection in 10(50%) cases, with expander exposure in eight(40%) patients, exposed valve line in three(15%) patients, and ischemia of flap in one(5%) patient. Some patients had more than one complication at the same time, resulting in failure of eight(40%) cases.

In the adult group(groupB), complications were present in only 30% of the cases where four(20%) patients developed infection, three(15%) patients developed exposed expander, and three(15%) patients had exposure of their valve lines. None of the patients had ischemia of the flap(0%), resulting in failure of only four(20%) cases. Therefore, in this study, infection was the most common complication resulting in expander exposure; recovery was bad in these patients and better in those with valve line exposure.

The time of expander removal varied from 3 to 12weeks after implantation according to the presence of complications, as severe infection with expander exposure caused rather early removal. Owing to the increased infection rate in children, they underwent earlier expander removal compared with the adult group with statistical significance(P=0.03).

Two cases, one from the children group and one from the adult group, showed inflamed skin over the implanted valve. The injection was postponed, and anti-inflammatory measures were taken; both conditions improved.

Previous studies have shown that the valve may be exposed from pressure necrosis. This may be due to the fact that often the valve is placed subcutaneously. To avoid this, the valve has to be completely exteriorized [8].

The best method for maximizing the use of expanded tissue in both vertical and horizontal directions is by scoring the capsule to increase flap advancement [5].

Cunha etal. [9] reported a 10-year experience with tissue expanders. The complication rate was 22.2%, and the most common causes were expander exposure(50%), infection(24%), and bad function of the expander(12.8%). Their study revealed an increased rate of minor complications in children aged 0–10years compared with patients aged 11–20years or patients older than 40years.

Friedman etal. [10] reported a 6-year experience with tissue expanders in children. The overall complication rate was 18%. The factors associated with a statistically significant increase in complications were burns and soft-tissue loss, patient age under 7years, use of internal expander ports, and a history of two or more previous expansions.

The results of these two studies are in agreement with this study: complications occurred more in children than in adults. The results of this study showed 55% complication in groupA compared with 30% in the adults group(groupB) and an increased failure rate in children(50%) than in adults(20%), with a statistically significant difference(P=0.4).


  Conclusion Top


Using tissue expanders is a reliable and safe method for reconstructing postburn alopecia with a very good outcome in adults rather than young children. It provides better results when performed after the age of 15 with minimal complications caused by infection and decrease in failure rates. Special care for scalp hygiene and early preoperative scalp shaving during preparation of patients are recommended to decrease the level of infection.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Inalöz HS, ChowdhuryMM, MotleyRJ. Lupus erythematosus/lichen planus overlap syndrome with scarring alopecia. JEur Acad Dermatol Venereol 2001; 15:171–174.  Back to cited text no. 1
    
2.
HassanAS. Surgical treatment of secondary cicatricial alopecia of scalp and eyebrow. Indian J Plast Surg 2009; 42:63–67.  Back to cited text no. 2
    
3.
Yeşilada AK, Akçal A, Tatlıdede HS. The feasibility of tissue expansion in reconstruction of congenital and acquired deformities of pediatric patients. Int J Burns Trauma 2013; 3:144–150.  Back to cited text no. 3
    
4.
McCauleyRL. Hair restoration, state of the art, tissue expansion reconstruction of the scalp. Semin Plast Surg. 2005; 19:143–152.  Back to cited text no. 4
    
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Hudson DA Maximizing the use of expanded flaps. Br J Plast Surg 2003; 56:784–790.  Back to cited text no. 5
    
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WaghMS, DixitV. Tissue expansion reconstruction of the scalp. Indian J Plast Surg 2013; 46:333–348.  Back to cited text no. 6
    
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Gürlek A, Alaybeyoğlu N, DemirCY, Aydoğan H, BilenBT, Oztürk A. Aesthetic reconstruction of large scalp defects by sequential tissue expansion without interval. Aesthetic Plast Surg 2004; 28:245–250.  Back to cited text no. 7
    
8.
KeskinM, KellyCP, YavuzerR, MiyawakiT, JacksonIT. External filling ports in tissue expansion: confirming their safety and convenience. Plast Reconstr Surg 2006; 117:1543–1551.  Back to cited text no. 8
    
9.
CunhaMS, NakamotoHA, HersonMR, FaesJC, GemperliR, FerreiraMC. Tissue expander complications in plastic surgery: a 10-year experience. Rev Hosp Clin Fac Med São Paulo 2002; 57:93–97.  Back to cited text no. 9
    
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FriedmanRM, IngramAE, RohrichRJ. Risk factors for complications in pediatric tissue expansion. Plast Reconstr Surg 1996; 98:1242.  Back to cited text no. 10
    


    Figures

  [Figure 1], [Figure2], [Figure3], [Figure4], [Figure5]
 
 
    Tables

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