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Year : 2017  |  Volume : 30  |  Issue : 4  |  Page : 978-983

Effect of quercetin treatment on hyperuricemic renal dysfunctions and hemodynamic parameters


1 Department of Physiology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Correspondence Address:
Heba F El-Domiaty
Department of Physiology, Faculty of Medicine, Menoufia University, Menoufia 32511
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_220_17

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Objective The aim of this study was to assess the potential effect of quercetin treatment on hyperuricemic renal dysfunctions and hemodynamic changes in in vivo and in vitro published studies. Materials and methods Data were obtained from Medline databases (PubMed, Medscape, ScienceDirect.) and all materials available in the internet from 2001 to 2016. The initial search presented 170 articles, of which 47 met the inclusion criteria. The articles studied the effect of quercetin treatment on hyperuricemic renal dysfunctions and hemodynamic changes. If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment included whether ethical approval was gained, eligibility criteria specified, appropriate controls, adequate information, and defined assessment measures. Comparisons were made using structured review with the results tabulated. Findings In total 47 potentially relevant publications were included. There was an association between hyperuricemia and renal function impairment together with deterioration of hemodynamic parameters. This association was due to hyperuricemic vascular endothelial dysfunction and oxidative stress. Studies concerned with quercetin treatment found that quercetin was able to improve hyperuricemic renal functions and hemodynamic parameter mainly due to its antioxidant effect. Conclusion Quercetin treatment improved hyperuricemic renal dysfunctions and hemodynamic parameters.


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