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 Table of Contents  
ORIGINAL ARTICLE
Year : 2017  |  Volume : 30  |  Issue : 3  |  Page : 870-875

Role of triphasic MRI in the diagnosis of hepatic focal lesions


1 Radiology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Radiology Department, National Liver Institute, Menoufia University, Menoufia, Egypt

Date of Submission13-Jun-2016
Date of Acceptance09-Oct-2016
Date of Web Publication15-Nov-2017

Correspondence Address:
Mostafa M Adel
Radiology Department, National Liver Institute, Menoufia University, 5 Taiseer Street, Shebein El kom, Menoufia Governorate, 32511
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-2098.218261

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  Abstract 

Objective
The aim of this study was to highlight the role of triphasic (dynamic) MRI in the diagnosis of hepatic focal lesions.
Background
MR of liver depends on the signal characteristics (T1-weighted and T2-weighted signal intensities) and post-Gd imaging. The combination of these imaging techniques provides anatomic and functional imaging information to best detect and diagnose liver pathology. Liver lesions were classified as malignant or benign on the basis of a combination of imaging features such as enhancement pattern/presence of fat, necrosis, and clinical features such as the presence of new/growing liver lesions and uncontrolled systemic disease.
Patients and methods
The study was conducted in the Hepatic Oncology Unit of the National Liver Institute, Menoufia University on 40 patients with focal hepatic lesions. The study was performed between January 2015 and February 2016.
Results
Out of the 40 patients studied (28 male and 12 female), 39 were found to have hepatic focal lesions and one had a well-defined hyperechoic area by ultrasound and revealed focal fatty infiltration when examined with dynamic MRI. Their ages ranged from 30 to 71 years, with a mean age of 52 years. Dynamic MRI was successfully performed in all patients, revealing 18 focal lesions to be benign, 21 malignant lesions, and one area of focal fatty infiltration.
Conclusion
MRI was found to be of considerable value in diagnosing and differentiating between the different cirrhotic hypervascular nodules. This technique can be implemented simply and reliably. It offers the advantages of significantly shorter acquisition times, retrospective thin-section or thick-section reconstruction from the same raw data, improved three-dimensional rendering, and high-quality liver imaging with high intrinsic soft-tissue contrast. It also provides a global overview of the abdomen. Its relative contraindications include renal impairment and sensitivity to IV contrast.

Keywords: hepatic focal lesions, hepatocellular carcinoma, triphasic MRI


How to cite this article:
Ali ZA, Abd Ella TF, Adel MM. Role of triphasic MRI in the diagnosis of hepatic focal lesions. Menoufia Med J 2017;30:870-5

How to cite this URL:
Ali ZA, Abd Ella TF, Adel MM. Role of triphasic MRI in the diagnosis of hepatic focal lesions. Menoufia Med J [serial online] 2017 [cited 2019 Dec 7];30:870-5. Available from: http://www.mmj.eg.net/text.asp?2017/30/3/870/218261


  Introduction Top


Medical innovation regarding the procedures for treatment of focal liver lesions, both primary and metastatic, has shown a significant increase of patient survey in such cases. Therefore, it is fundamental to identify the presence of focal liver lesions early as well as to characterize the nature of such lesions, as benign or malignant, accurately to establish the appropriate treatment planning [1].

MRI represents the current technique of choice in this setting as it is free of ionizing radiation and also because it shows high contrast resolution using several sequences and different types of contrast media. In this regard, the more commonly used MR contrast media are represented by gadolinium chelates, which show an extracellular hepatic distribution, whereas the intracellular contrast media consist of compounds with biliary excretion or those with distribution in the reticuloendothelial system cells [1].

Although liver parenchyma are fed by both the hepatic artery and portal vein, classical hepatocellular carcinoma (HCC) is usually fed by the hepatic artery only. In particular dynamic, computed tomography (CT) or MRI is essential for the diagnosis of liver tumors. Moreover, MRI with tissue-specific MR contrast media and enhanced ultrasonography with real-time high-spatial-resolution imaging have recently become clinically available [2].

Focal nodular hyperplasia (FNH) is the second most common benign hepatic tumor and is believed to be the result of a hyperplastic response of hepatocytes to the presence of a pre-existing vascular malformation. Hepatocellular adenoma is another benign hepatic tumor that occurs predominantly in young women who are receiving oral contraceptives or other steroid medications. MRI is widely used for the differential diagnosis of these lesions. A number of characteristic MRI findings, such as central vascular scar for FNH or signal dropout on fat-suppressed images for hepatocellular adenoma, may be useful, and the dynamic contrast enhancement profile of each tumor when standard gadolinium-based chelates are used can provide additional diagnostic information [3].

The progressive differentiation of a regenerative nodule to a dysplastic nodule, and then to an early-HCC has been well investigated. In this differentiation, the nodule increases its arteriolar supply progressively and reduces the portal vascularization. This vascular change is a crucial step in the carcinogenesis. In view of this consideration, HCC diagnosis with imaging techniques is based on a 'vascular analysis' of enhancing pattern, with an increased signal intensity or 'wash-in' during the arterial phase and a 'wash-out' pattern in the portal or equilibrium phase [4].

Gadolinium-enhanced imaging revealed increased tumor vascularity in the hepatic arterial phase. Increased conspicuity of hypervascular tumors with gadolinium-enhanced images was achieved because of the strong T1-shortening effect of gadolinium chelates injected as a bolus, good T1-weighted contrast resolution of the spoiled gradient-recalled echo sequence, and the use of phased-array multicoil [5].


  Patients and Methods Top


Study population

A total of 40 patients with focal hepatic lesions were included in this study. The study was performed between January 2015 and February 2016. The study was conducted in the National Liver Institute through the Hepatic Oncology Unit.

Inclusion criteria

Patients known to have a single or multiple hepatic focal lesions detected by ultrasound and/or triphasic CT.

The patients were subjected to the following:

  • Full clinical assessment including recording of age, sex, and clinical presentation.
  • Laboratory investigations included liver biochemical profile, renal function tests, and α-fetoprotein.
  • Abdominal MRI (precontrast and postcontrast study and diffusion-weighted imaging) was performed by a GE optima MR450w 1.5T (Chicago, USA). The results were compared with laboratory, histopathology (if available), and other previous radiological (ultrasound and/or triphasic CT) findings obtained for all patients.


The MR protocol used

Precontrast imaging included

  • T1-weighted (T1W) images: repetition time (TR)=10 ms, echo time (TE) = 4.58 ms, matrix 179/320, slice thickness 7–8 mm, slice gap 1–2 mm, and FOV = 355 mm
  • T2-weighted (T2W) images (single-shot free breathing): TR ≥ 445 ms, TE = 26–28 ms, matrix 180–200 × 240 with a field of view = 365, slice thickness 7–8 mm, slice gap 1–2 mm
  • T2 fat suppression sequence: TR ≥ 400 ms, TE = 80 ms, matrix 204 × 384 with a field of view = 365, slice thickness 7–8 mm, slice gap 1–2 mm
  • In-phase and out-phase gradient echo sequence (dual/fast field echo): TR = 75–100 ms, TE = 4.6 ms for in phase and 2.3 ms for out phase, matrix 143 × 240 with a field of view = 345, slice thickness 7–8 mm, slice gap 0 mm
  • Heavy T2-weighted images: TR = 520 ms, TE = 200 ms, matrix 235/384 with a field of view = 375, slice thickness 7–8 mm, slice gap 1–2 mm.


Dynamic study

Dynamic study was performed after a bolus injection of 0.1 mmol/kg body weight of Gd-DTPA at a rate of 2 ml/s, flushed with 20 ml of sterile 0.9% saline solution from the antecubital vein. The injection of contrast media and saline solution was performed manually. Dynamic imaging using the T1 technique was performed in the triphasic way [arterial phase (16–20 s), portovenous phase (45–60 s), and delayed equilibrium phase (3–5 min)] after administration of contrast media.

Imaging evaluation

Morphological features of each lesion were recorded, including size, shape, margin, signal characteristics, pattern of enhancement in the dynamic imaging, as well as the number and site of the detected focal lesions. Then, the provisional diagnosis was reported.

The results were compared and correlated with other radiological and laboratory results in all patients.


  Results Top


Out of the 40 patients studied (28 male and 12 female), 39 were found to have hepatic focal lesions and one had a well-defined hyperechoic area by ultrasound and revealed focal fatty infiltration when examined with dynamic MRI. Their ages ranged from 30 to 71 years with a mean age of 52 years. Dynamic MRI was successfully performed in all patients, revealing 18 focal lesions to be benign, 21 malignant lesions, and one area of focal fatty infiltration.

Hepatic focal lesions were divided to the following categories as shown in the chart and table below: malignant tumors (18 cases of HCC, three secondaries), benign tumors (seven cases of hemangioma, one case of abscess, four cases of regeneration nodules and four cases of simple hepatic cysts), two cases of dysplastic nodules, and one case of focal fat infiltration area [Table 1].
Table 1: Disease distribution in the recruited patients (n=40)

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Most of the HCC lesions followed pattern 1 (78%), whereas the rest followed different patterns as shown in [Table 2].
Table 2: Patterns of enhancement of hepatocellular carcinoma in different dynamic phases in the recruited patients (n=18)

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All of the hemangioma lesions followed pattern 1 (100%), whereas no other lesions followed different patterns [Table 3].
Table 3 Patterns of enhancement of hemangioma in different dynamic phases in the recruited patients (n=7)

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Most of the metastatic lesions followed pattern 1 (66.5%), whereas the rest of the lesions followed pattern 2 (33.4%) [Table 4].
Table 4 Patterns of enhancement of metastatic lesions in different dynamic phases in the recruited patients (n=3)

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Most of the regeneration nodules followed pattern 3 (50%), whereas the other lesions followed different patterns [Table 5].
Table 5 Patterns of enhancement of regeneration nodules in different dynamic phases in the recruited patients (n=2)

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  Discussion Top


In this study, we noticed that the dynamic study of the majority of HCC lesions displayed the typical early arterial enhancement and contrast washout in the portal and delayed phases. These findings were also similar to the publications of Mannelli and Rosenkrantz [6], who stated that the arterial enhancement (hypervascularity) and delayed hypointensity are considered as essential characteristic features of HCC as the tumor recruits unpaired arteries and sinusoidal capillaries with resultant avid arterial enhancement. Rarely, HCC may remain hyperintense relative to the adjacent liver parenchyma on venous and delayed phase images. However, HCC may be hypovascular to the surrounding liver parenchyma on the immediate gadolinium-enhanced images, and this may be related to the lack of arterialization of the tumor, and in these cases diagnosis by imaging is difficult and biopsy is essential [6].

In the study, vascular invasion into the portal vein was not noticed in any case of HCC lesions. However, Chen et al. [7] who reported that malignant portal vein thrombosis in association with HCC is demonstrated by the same signal intensity and contrast-enhancement pattern as the primary tumor.

Regarding the other cases that are not HCC, we found imaging criteria that suggest cirrhotic features of the liver, and some of the them showed early cirrhotic changes; we found suspicious lesions within the liver, and further investigations and imaging was essential to be sure of the nature of these lesions and to determine how to deal with them.

Regarding hemangiomata cases, however, hemangiomas rarely occur in end-stage cirrhosis, probably because the cirrhosis obliterates existing hemangiomas. When present in the cirrhotic liver, they are often atypical and contain large areas of fibrosis. They do not wash out and instead remain isointense relative to the liver [8].

Radiologic features of 'peripheral nodular enhancement and progressive fill-in' are the most typical of cavernous hemangiomas with contrast enhanced dynamic MRI as reported by Kato et al. [8].

In this study, we have seven cases of hemangioma; all of them were relatively typical in appearance.

Specific CT and MRI findings that are important to recognize the characterization of cystic focal liver lesions are the size of the lesion; the presence and thickness of a wall; the presence of septa, calcifications, or internal nodules; the enhancement pattern; the MR cholangiographic appearance; and the signal intensity spectrum. In addition, access to critical clinical information remains extremely important. The most important clinical parameters defined include age and sex, clinical history, and symptoms [9].

The spectrum of multilocular cystic hepatic lesions includes common and uncommon entities. A lesion's cystic components and internal septa usually reflect its underlying pathologic basis, although imaging findings are not always specific [10].

In this study, there were four cases of hepatic cysts; all have homogeneous very low signal intensity on T1-weighted images and homogeneous very high signal intensity on T2-weighted images with no enhancement after administration of gadolinium chelates as reported by Mortele and Ros [9].

One case of pyogenic liver abscess with criteria similar to that was reported by Mortele and Ros [9]: a multiseptated large abscess can be observed that shows rim and septa enhancement with a characteristic target appearance (the 'double target' sign).

The diagnosis of hypervascular metastatic lesions was more or less easier by knowing that the patients have primary malignancy; hence, this raises the importance of searching for a primary malignancy in cases we find multiple hepatic nodular lesions even in cirrhotic patients.

Murakami and Tsurusaki [11] reported that when the primary lesion is known, metastatic tumors can be easily diagnosed.

Hanna et al. [12] reported that regenerative nodules are the most common cirrhosis-associated hepatocellular nodules.

There were four cases included in the study that showed multiple scattered regeneration nodules. The use of dynamic MRI helps further in the detection of these suspicious nodules by identifying the enhancement pattern of these nodules. This raises the effectiveness and usefulness of dynamic MRI in the evaluation and characterization of hepatic focal lesions.

After contrast administration, regenerative nodules RNs show enhancement similar to the normal liver parenchyma in all phases and they are usually smaller than 2 cm as reported by Mannelli and Rosenkrantz [6].

In our study, there were no lesions diagnosed as FNH; however, FNH is a benign hypervascular tumor arising from the normal liver parenchyma. It occurs primarily in young women; it is solitary in about 75–80% of the patients. The typical imaging findings of FNH are a central scar, intratumoral centrifugal arteries from the center, and the presence of Kupffer cells and the proliferation of cholangiole, among others, which was postulated by Murakami and Tsurusaki [11] [Figure 1], [Figure 2], [Figure 3], [Figure 4].
Figure 1: A case of liver hemangioma: dynamic MRI abdomen and pelvis findings: segments V, VII, and VIII have well-defined large focal lesions measuring about 15 × 10 cm showing the following features: low signal on T1 (a), bright signal (light bulb) on T2 (b), bright signal on diffusion-weighted images (DWI) (c), peripheral contrast enhancement at the arterial (d), and gradual filling at portovenous phase (e).

Click here to view
Figure 2: A case of liver cyst: dynamic MRI abdomen and pelvis findings: single hepatic focal lesion seen at segment VI (1.5 cm) showing the following features: hypointense on T1 (a), hyperintense on T2 showing water signal (b), hyperintense on diffusion-weighted images (DWIs) (c), and no enhancement is noted after contrast in the arterial, portovenous, and delayed phases (d, e).

Click here to view
Figure 3: A case of hepatocellular carcinoma: dynamic MRI abdomen and pelvis findings: well-defined solid focal lesions seen at segment V showing the following features: hypointense on T1 (a), slightly hyperintense on T2 (b), restricted diffusion on diffusion-weighted images (c), contrast enhancement at the arterial (d), and wash out at delayed phase (e).

Click here to view
Figure 4: Suspected liver metastasis for metastatic work up: dynamic MRI abdomen and pelvis findings: multiple bilobar hepatic focal lesions were found, the largest measuring 15 cm; the lesions show the following features: hypointense on T1 (a), heterogeneous intensity on T2 (b), hyperintense on DWI (c), peripheral ring enhancement on arterial phase (d), and no definite wash out in delayed phases (e).

Click here to view



  Conclusion Top


So far, MRI was found to be of considerable value in diagnosing and differentiating between different cirrhotic hypervascular nodules. This technique can be implemented simply and reliably. It offers the advantages of significantly shorter acquisition times, retrospective thin-section or thick-section reconstruction from the same raw data, improved three-dimensional rendering, and high-quality liver imaging with high intrinsic soft-tissue contrast. It also provides a global overview of the abdomen. Its relative contraindications include renal impairment and sensitivity to IV contrast.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
  References Top

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Ryeom HK, Kim SH, Kim JY, Kim HJ, Lee JM, Chang YM, et al. Quantitative evaluation of liver function with MRI using Gd-EOB-DTPA. Korean J Radiol 2004; 5:231–239.  Back to cited text no. 1
    
2.
Grazioli L, Bondioni MP, Haradome H, Motosugi U, Tinti R, Frittoli B, et al. Hepatocellular adenoma and focal nodular hyperplasia: value of gadoxetic acid-enhanced MR imaging in differential diagnosis. Radiology 2012; 262:520–529.  Back to cited text no. 2
    
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Maetani Y, Itoh K, Watanabe C, Shibata T, Ametani F, Yamabe H, Konishi J. MR imaging of intrahepatic cholangiocarcinoma with pathologic correlation. AJR Am J Roentgenol 2001; 176:1499–1507.  Back to cited text no. 3
    
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Palmucci S. Focal liver lesions detection and characterization: the advantages of gadoxetic acid-enhanced liver MRI. World J Hepatol 2014; 6:477–485.  Back to cited text no. 4
    
5.
Haimerl M, Wächtler M, Platzek I, Müller-Wille R, Niessen C, Hoffstetter P, et al. Added value of Gd-EOB-DTPA-enhanced hepatobiliary phase MR imaging in evaluation of focal solid hepatic lesions. BMC Med Imaging 2013; 13:1–8.  Back to cited text no. 5
    
6.
Mannelli L, Rosenkrantz A: Focal lesions in the cirrhotic liver. World J Hepatol 2015; 7:468–487.  Back to cited text no. 6
    
7.
Chen ML, Zhang XY, Qi LP, Shi QL, Chen B, Sun YS. Diffusion-weighted images (DWI) without ADC values in assessment of small focal nodules in cirrhotic liver. American J Roentgenology 2014; 26:38–47.  Back to cited text no. 7
    
8.
Kato H, Kanematsu M, Matsuo M, Kondo H, Hoshi H. Atypically enhancing cavernous hemangioms: high spatial resolution gadoxetic acid enhanced triphasic dynamic gradient recalled echo imaging findings. Eur Radiol 2001; 11:2510–2515.  Back to cited text no. 8
    
9.
Mortele K, Ros P: Cystic focal liver lesions in the adult: differential CT and MR imaging features. Radiographics 2001; 21:895–910.  Back to cited text no. 9
    
10.
Qian LJ, Zhu J, Zhuang ZG, Xia Q, Liu Q, Xu JR. Spectrum of multilocular cystic hepatic lesions: CT and MR imaging findings with pathologic correlation. Radiographics 2013; 33:1419–1433.  Back to cited text no. 10
    
11.
Murakami T, Tsurusaki M. Hypervascular benign and malignant liver tumors that require differentiation from hepatocellular carcinoma: key points of imaging diagnosis. Liver Cancer 2014; 3:85–96.  Back to cited text no. 11
    
12.
Hanna R, Aguirre D, Kased N. Cirrhosis-associated hepatocellular nodules: correlation of histopathologic and MR imaging features. Radiographics 2008; 28:747–769.  Back to cited text no. 12
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4]
 
 
    Tables

  [Table 1], [Table 2], [Table 3], [Table 4], [Table 5]



 

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