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ORIGINAL ARTICLE
Year : 2017  |  Volume : 30  |  Issue : 3  |  Page : 679-686

The correlation between residual renal function and inflammation in chronic hemodialysis patients


1 Department of Biochemistry, Internal Medicine and Nephrology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Nephrology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
3 Department of Internal Medicine and Nephrology, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Correspondence Address:
Elsayed G Mahros
Zagazig, Sharqia, 44661
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-2098.218266

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Objective The aim of the study was to study any possible correlation between inflammation and residual renal function (RRF) in chronic hemodialysis (HD) patients. Background RRF plays an important role in maintaining fluid balance, phosphorus control, nutrition, and removal of middle molecular uremic toxins. Decline of RRF also contributes significantly to anemia, inflammation, and malnutrition in patients on dialysis. Inflammation and activation of acute-phase responses are common in chronic kidney disease patients. The causes of inflammation in HD patients are multifactorial. Inflammatory reaction may originate from several sources, including graft or fistula infections, bioincompatible dialysis membrane, dialysate, endotoxin exposure, back filtration, chronic infections, and malnutrition. High-sensitivity C-reactive protein (hsCRP) assay is useful for sensitive detection of the inflammatory state. Patients and methods Fifty patients on regular HD were divided into two groups: group 1 comprising 25 patients with RRF and group 2 comprising 25 patients without RRF. Estimation of hsCRP and serum albumin and calculation of RRF were carried out. Results The mean and SD of hsCRP in HD patients without RRF was 14.90 ± 11.58 mg/l and that in HD patients with RRF was 5.71 ± 3.56 mg/l (P = 0.000). There was significant negative correlation between hsCRP and residual kidney function (r = −0.574) in group 1. There was no statistically significant difference between groups regarding serum albumin. Conclusion The levels of hsCRP were found to be elevated in chronic kidney disease on dialysis patients. There was a significant relationship between reduced glomerular filtration rate and hsCRP levels.


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