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ORIGINAL ARTICLE
Year : 2017  |  Volume : 30  |  Issue : 2  |  Page : 525-531

Comparative study using cyclosporine A 0.05% eye drops, autologous serum 20% eye drops, and combined use of cyclosporine A 0.05% eye drops and autologous serum 20% eye drops in the treatment of moderate to severe dry eye


Department of Ophthalmology, Faculty of Medicine, Menoufia University, Shebeen Al-Koom, Menoufia, Egypt

Correspondence Address:
Mohammad A Al-Sayed Ahmad Kasper
3 Sheraton Al-Matar, Area 4, Al-Nozha, Cairo, 11843
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-2098.215461

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Objectives A comparative study was carried out between the cyclosporine A 0.05%, the autologous serum, and combined therapy of both in the treatment of moderate to severe dry eye. Background Dry eye disease is a common and often underdiagnosed condition. Patients and methods A prospective interventional case study was carried out on 30patients attending the ophthalmology outpatient clinic of Menoufia University; these patients were subdivided as follows: groupA received topical autologous serum 20% four times daily for 2months, groupB received cyclosporine A emulsion 0.05% twice daily for 2months, and groupC received topical cyclosporine A emulsion 0.05% two times daily and topical autologous serum 20% four times daily for 2months. The three groups received nonpreserved tears up to five times daily, to be followed 1month after stoppage of treatment, except for nonpreserved tears(Refresh Plus). All patients were subjected to a full assessment of history, slit-lamp examination, lissamine green staining of the ocular surface, the tear break-up time test, Schirmer's test, and conjunctival impression cytology before treatment, at 1 and 2months after treatment, and then 1month after stoppage of treatment. The results obtained were subjected to a statistical analysis. Results In our study, we found that autologous serum eye drops had a more delayed onset of action, but more sustained action; topical cyclosporine A had a rapid onset of action, but regression occurred soon after stoppage of treatment. Both autologous serum and cyclosporine 0.05% had additive effects with a rapid sustained action. Conclusion Combined topical cyclosporine A emulsion 0.05% and autologous serum eye drops 20% are effective in the treatment of dry eye cases through their combined anti-inflammatory and epitheliotropic effects. Therefore, we recommend the use of combined autologous serum 20% and cyclosporine 0.05% in the treatment of severe dry eye.


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