Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2017  |  Volume : 30  |  Issue : 1  |  Page : 255-261

Seroprevalence of human parvovirus B19 immunoglobulin G in children with hematological disorders and healthy children


1 Department of Medical Microbiology and Immunology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Ophthalmology Hospital, Shebin El-Kom, Menoufia, Egypt

Correspondence Address:
Seham A El Shorbagy Eissa
Shebin El-Kom, Menoufia, 32511
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_74_16

Rights and Permissions

Objective The aim of this study was to determine the serum levels of anti-parvovirus B19 immunoglobulin-G (IgG) and its prevalence in children with hematological disorders and in apparently healthy children in Menoufia University Hospitals. Background Parvovirus B19 infections can suppress erythropoiesis and induce acute erythroblastopenia, which is often referred to as transient aplastic crisis in patients with chronic hemolytic anemia such as sickle cell anemia, thalassemia, and hereditary spherocytosis. Patients and methods The study was conducted on 60 children with chronic hemolytic anemia (40 children with chronic hemolytic anemia without a history of aplastic crisis and 20 children with chronic hemolytic anemia with a history of aplastic crisis) and 20 age-matched and sex-matched apparently healthy children. All patients were subjected to full history taking, clinical examination, and laboratory investigations. Serum anti-parvovirus B19 IgG levels were measured using anti-parvovirus B19 ELISA kits. Results The prevalence of anti-parvovirus B19 IgG antibodies in the sera of chronic hemolytic anemia children with and without a history of aplastic crisis was 62.5 and 100%, respectively. Seropositivity of anti-parvovirus B19 IgG antibodies was 20% in apparently healthy children. Seropositivity of anti-parvovirus B19 IgG antibodies in children with β-thalassemia major and sickle cell anemia was 78 and 100%, respectively. Significant positive correlations were detected between age of the children, frequency of blood transfusion, and the level of anti-parvovirus B19 IgG. Conclusion The prevalence of anti-parvovirus B19 IgG antibodies was higher in all chronic hemolytic anemia children, particularly in those with a history of aplastic crisis. Furthermore, all children with β-thalassemia major and sickle cell anemia with a history of aplastic crisis had anti-parvovirus B19 IgG antibodies.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed319    
    Printed0    
    Emailed0    
    PDF Downloaded53    
    Comments [Add]    

Recommend this journal