Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2017  |  Volume : 30  |  Issue : 1  |  Page : 190-195

Plasma vitamin C concentration in chronic kidney disease: Comparison between diabetic and nondiabetic patients


1 Department of Internal Medicine, Faculty of Medicine, Menoufia University, Shibin Al Kom, Egypt
2 Department of Microbiology, Faculty of Medicine, Menoufia University, Shibin Al Kom, Egypt
3 Department of Nephrology, Alamrya General Hospital, Alexandria, Egypt

Correspondence Address:
Saad M Mohammed Elgengaihy
Tanta, Gharbia, 31511
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-2098.211501

Rights and Permissions

Objective The aim of the study is to evaluate the relationship between renal functions and plasma vitamin C concentration in nondiabetic and diabetic patients with chronic kidney disease. Background A decreased plasma level of vitamin C has been reported to be associated with an increased risk of cardiovascular morbidity and mortality. Here, we sought to determine the vitamin C status of patients with chronic kidney disease and the pathophysiological role of vitamin C in these patients. Patients and methods A total of 50 patients were included in the study and classified into two groups: group I, patients with chronic kidney disease with diabetes and group II, patients with chronic kidney disease without diabetes. The relationship between renal function and plasma vitamin C concentration was evaluated, as well as the effect of diabetes on this relationship. Results Statistical comparison revealed a significant statistical increase in the mean value of vitamin C level in the group II compared with group I (P ≤ 0.001). Also, there was a significant positive correlation between vitamin C level and both weight and estimated glomerular filtration rate in the patients, whereas there was a significant negative correlation between vitamin C level and each of serum creatinine level, blood urea level, albumin–creatinine ratio, and glycosylated hemoglobin level in the patients. Conclusion Renal dysfunction was associated with a decreased level of plasma vitamin C in patients with chronic kidney disease. Diabetic patients showed a lower level of vitamin C at any given estimated glomerular filtration rate compared with nondiabetic patients.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed585    
    Printed0    
    Emailed0    
    PDF Downloaded51    
    Comments [Add]    

Recommend this journal