Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2016  |  Volume : 29  |  Issue : 2  |  Page : 265-268

Effect of omega-3 supplementation on lipid profile and inflammatory markers in children on chronic hemodialysis


Department of Pediatrics, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Correspondence Address:
Mohamed A Mohamed Elsayed
61 Portsaid Street, Quesna, 32631 Menoufia
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-2098.192431

Rights and Permissions

Objectives: The aim of this study was to evaluate the effect of omega-3 supplementation on the lipid profile and inflammatory markers in children on chronic hemodialysis. Background: Children with end-stage renal disease on hemodialysis are at a high risk of adverse cardiovascular events. Dyslipidemia is an important risk factor for cardiovascular morbidity and mortality in dialysis patients, Patients who are on hemodialysis have elevated serum levels of inflammatory markers. There is a growing interest in the application of omega-3 fatty acids in the prevention of cardiovascular disorders in dialysis patients. Omega-3 fatty acids have been postulated to reduce proinflammatory response, confer antithrombotic properties, improve lipid levels (particularly triglycerides), and improve endothelial function. Materials and methods: This clinical trial was conducted in 23 children with end-stage renal disease undergoing dialysis in the pediatric hemodialysis unit of Menoufia University Hospitals. The patients received 1 g omega 3 per day for 3 months. Blood samples were obtained from the patients studied before and at the end of the study for hemoglobin, ferritin, triglyceride, total cholesterol, LDL-c and HDL-c, and high specific-C-reactive protein measurement, and the differences were analyzed. Results: Of 23 patients, 12 were males and 11 were females, mean age 14.52 (8–18) years. There were statistically highly significant differences between the level of triglycerides before (148.86 ± 44.41 mg/dl), and after supplementation with omega-3 fatty acid (135.17 ± 45.99 mg/dl) (P<0.001). The differences found in hemoglobin, parathyroid hormone, ferritin, C-reactive protein, LDL-c, and HDL-c before and after supplementation with omega-3 fatty acid were not statistically significant (P> 0.05). Conclusion: The use of omega 3 led to a significant decrease in serum levels of triglycerides in children on hemodialysis, and its use may be recommended in such patients.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed892    
    Printed13    
    Emailed0    
    PDF Downloaded83    
    Comments [Add]    

Recommend this journal