Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2016  |  Volume : 29  |  Issue : 2  |  Page : 215-221

A study on how patients catch hepatitis C virus


Department of Internal Medicine, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Correspondence Address:
Kamal A Mohamed
Biala-AbdEl-Monem Riad Street, Kafr El-Sheikh Governorate, 33634
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-2098.192443

Rights and Permissions

Objective: The aim of this study was to evaluate the prevalence of hepatitis C virus (HCV) and its mode of transmission in Kafr El-Sheikh governorate. Background: The overall prevalence of antibody to HCV in the general population is around 15–20%. Knowledge of the risk factors and clinical outcome of hepatitis C will provide important information regarding treatment and public health guidelines. Patients and methods: Data were collected on patients exposed to risk factors for HCV transmission or have clinical manifestation of liver cell failure from among outpatients and inpatients at the Liver Institute, Kafr El-Sheikh governorate. Two hundred patients who were HCV positive and 60 patients who were HCV negative, determined according to the one-step test device by ACON Laboratories, were included as cases and controls, respectively. Patients recently exposed to sources of risk factors (at least 6 weeks) were excluded from the study. All the study participants were subjected to history taking and complete physical examination. Results: The study showed that 200 of the studied samples were seropositive (cases), and 60 were seronegative (control). With regard to the risk factors to which the patients were exposed, there were highly significant differences in patients than in controls in relation to blood transfusion, family history, antischistosomal drug (tartar emetic), and surgery. The most significant cause of HCV transmission was intrafamilial exposure [odds ratio (OR) = 8.522, 95% confidence interval (CI) 3.704–19.605], followed by antischistosomal drug injection (OR = 3.905, 95% CI 1.605–9.503) and blood transfusion (OR = 0.2, 95% CI 0.099–0.743). Conclusion: There are several modes of transmission. The most significant cause of HCV transmission was intrafamilial exposure, followed by antischistosomal drug injection and blood transfusion. There should be focus on preventing HCV by reducing its transmission, particularly among those at risk of acquiring the virus. Screening of all family members of HCV-infected patients should be made mandatory.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed906    
    Printed7    
    Emailed0    
    PDF Downloaded75    
    Comments [Add]    
    Cited by others 1    

Recommend this journal