Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
REVIEW ARTICLE
Year : 2015  |  Volume : 28  |  Issue : 2  |  Page : 282-288

Clinical aspects of the haemostasis-inflammation interface


Department of Internal medicine, Al-Mahallah al-Kubra Hospital, Menoufia University, Menoufia Governorate, Egypt

Correspondence Address:
Wael R Abu-Sabala
Al-Mahallah al-Kubra, Bolkina 31951
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-2098.163865

Rights and Permissions

Objective The aim of the study was to evaluate the clinical aspects of the haemostasis and inflammation interface. Data sources Data sources were medical text books, medical journals and medical websites that have updated research with keywords (haemostasis and inflammation) in the title of the paper. Study selection Systematic reviews that addressed haemostasis and inflammation and the role of haemostasis and inflammation in clinical studies were included. Data extraction A special search was performed in MEDLINE with keywords (haemostasis and inflammation) in the title of the papers; extraction was performed, including assessment of the quality and validity of the papers that met the prior criteria that describe haemostasis and inflammation and their role in clinical studies. Data synthesis It included the main result of the review. Each study was reviewed independently; the obtained data were rebuilt in a new language according to the need of the researcher and arranged in topics through the article. Conclusion Improved understanding of the molecular mechanisms that play a role in the bidirectional relationship between inflammation and haemostasis could help in the clinical management of patients by identifying new potential therapeutic targets that can modify excessive and inappropriate activation or deregulation of both systems. On the basis of experimental and clinical studies, it is likely that simultaneous modulation of both inflammatory and haemostatic activities, rather than specific therapy aimed at only one component, could be more successful in the treatment of clinical states and diseases in which a close link between inflammation and haemostasis considerably contributes to the pathogenesis or progression of the disease.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed682    
    Printed14    
    Emailed0    
    PDF Downloaded117    
    Comments [Add]    

Recommend this journal